In a living room, kitchen or hallway, set Smart Humidity mode to 50-55%. The unit switches itself off at that level and restarts when humidity creeps back up, so it does not hum all day. Going below about 45% makes the compressor work harder for little gain and leaves the air drier than most people like.
For laundry, use the dedicated mode. It runs at full power for six hours and then stops, which suits a full airer in a closed room. Spread the clothes out rather than bunching them, and keep the machine a metre or so away so air can circulate.
In a bedroom, night mode dims the display and drops the fan to its quietest setting. At 40dB that is a steady, low hum, so a light sleeper should try it for a night or two before relying on it.
In a garage, caravan or cold outbuilding, remember that every compressor dehumidifier loses efficiency as the temperature falls. Below roughly 10-15°C a desiccant model such as the Meaco DD8L will extract more water.
If the unit never reaches its target and runs flat out, the room is either larger than it can handle or moisture is arriving as fast as it is removed, from wet washing, cooking or an unvented bathroom. Fixing the source with an extractor fan or better ventilation helps more than any setting.
Empty the tank when the full-tank light comes on, or connect a drain hose to run it continuously. Wipe the intake grille now and then and change the HEPA filter about once a year.